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The influence of various groups of pharmacological agents on cortisol
Author: Yuri Klimishin - an iron enthusiast and veteran of the "chemical" front. All articles by the author ➤
Important! We do not advocate for the use of steroids and other potent substances. All information is provided so that those who still decide to take them can do so with minimal health risks. On this website, there is an article about cortisol as a hormone necessary for the physical existence of the human body. Here it is. Now let's consider how various AAS and related drugs, such as antiestrogens or Growth Hormone, affect the behavior of one's own cortisol. There will be no medications here that directly affect the production of cortisol by the body. Such things should only be prescribed by an endocrinologist. We will only discuss its (cortisol's) blockers. More specifically, the blockers of its receptors in muscle tissue. Testosterone is the best, most effective, and proven anti-catabolic. If you are on a continuous testosterone cycle, you need to pay attention to your nutrition and rest. Testosterone can help deal with cortisol. Monoesters such as testosterone propionate, enanthate, and cypionate are ideal for this task. Testosterone, Methandrostenolone, Oxymetholone, Oxandrolone, Turinabol - the most powerful blockers of cortisol receptors. Methyltestosterone, Nandrolone, Boldenone, Methenolone enanthate – are somewhere in the middle. Drostanolone, Trenbolone, Stanozolol – do not possess anti-catabolic effects at all. But that’s in theory. In practice, taking any AAS at a working dose significantly shifts the body towards anabolism. And cortisol's activity in breaking down muscle is sharply reduced. All medications are listed in order of effectiveness. During the cycle, everything is clear. Regarding PCT, all the muscles that you gained as a bonus (the mass that is not genetically predetermined) will gradually disappear after complete cessation of AAS. Accept this. I advise using nothing except Anastrozole and only for controlling Estradiol during the cycle. In reasonable doses, it does not affect cortisol at all. However, the abuse of Anastrozole, and especially other AIs, is a direct path to halting anabolism altogether. Tamoxifen, Clomid, etc. If taken as it should be – strictly during PCT and no more – they have no impact on cortisol receptors. Probably the only thing I can recommend for those on cycles - is to use it during breaks between cycles. This will help strengthen your skeleton. GH is a decent anti-catabolic. When present during PCT and/or breaks, you'll maintain your gains longer. But that is from 10 IU per day. Anything less is insignificant, strictly for overall health. And the specific GH product should already be familiar to you, effective for you. Remember, different people respond to different GH. The most powerful anti-catabolic that I know of. It is enough to quickly raise your insulin levels after heavy training, and your muscle will start breaking down more slowly. However, using insulin is FAR from suitable for everyone. For VERY different reasons. This is especially true for those who are not quite lean by nature. I have often seen situations where such a guy tried to combat catabolism during PCT using insulin, and in the end, he just added a couple of kilograms of fat. Of course, he didn't lose muscle, but who needs that? Recently, I have been very disappointed with the quality of the vials that ordinary mortals can buy online. In general, if a couple of peptides actually delivered the promised effect, they would be quite suitable for the period between AAS cycles. Never had direct anti-catabolic abilities. This is all made up. It can indeed slow down protein breakdown in skeletal muscles, but EXCLUSIVELY against the background of a low-carbohydrate diet and a weight loss regimen in the body. All the good anti-catabolics from the above-listed bind to cortisol receptors in muscle tissue (mainly), and this hormone stops intensely breaking down muscle in our bodies. Naturally, this leads to increased production of cortisol. The situation is analogous to the behavior of estradiol when using blockers like Tamoxifen. So, we cannot completely take control of our own cortisol. We can only try to compete with it in terms of preserving the maximum amount of muscle in the body. That’s it. Good luck. SIMILAR ARTICLES
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